Your Comprehensive Guide To Nutrination Skin Boosters - 2025

Your Comprehensive Guide To Nutrination Skin Boosters - 2025

Comprehensive Guide to Anti‑Aging Skin Boosters

Explore the cutting‑edge world of skin rejuvenation, from collagen‑stimulating biostimulators to hydrating hyaluronic cocktails, polynucleotide repair complexes, exosomes, brightening blends, eye boosters and more. This guide maps out each NutriNation product category and outlines how the active ingredients work, with honest pros and cons and who each option suits best.

Before You Begin

While these formulations can provide impressive improvements—firming, smoothing, hydrating, evening tone—the results depend on proper technique, lifestyle, and aftercare.

Note on categories: To keep this guide digestible, products are grouped by their core active ingredients. For each class we describe the general mechanism supported by research, then list products in that category with typical benefits and considerations.

Table of Contents

Collagen Stimulators (PLA/PLLA/PDLLA & PCL) Polynucleotide & PDRN Boosters Hyaluronic Acid & Revitalizing Cocktails Exosome‑Based Boosters Brightening & Antioxidant Cocktails Eye‑Specific Boosters Masks & Peels NAD+ & Cellular Energy Unique & Miscellaneous Formulations Comparison Table FAQ

Collagen Stimulators (PLA/PLLA/PDLLA & PCL)

Collagen stimulators are injectable biostimulators that create a controlled inflammatory response, coaxing your skin to build its own collagen matrix over months. Poly‑L‑lactic acid (PLLA), poly‑D,L‑lactic acid (PDLLA) and polycaprolactone (PCL) microparticles trigger fibroblasts and macrophages to deposit types I and III collagen, gradually thickening and tightening the dermis. These particles degrade into lactic acid or caproic acid over time, continuing to stimulate new collagen as they break down. Results appear gradually and can last 18–24 months.

PCL formulations like Gouri are fully liquid; they spread smoothly throughout the tissue and stimulate natural collagen synthesis, improving elasticity and firmness while preserving a natural look with minimal downtime.

Notable Products

  • Rejeunesse Sparkle (2.5ml × 3) – PLA microspheres with HA gel for subtle volumization and skin tightening.
  • Juvelook 50 mg (PLA + HA) – fine biostimulator for acne scars and pores; blends PLLA particles with hyaluronic acid for hydration.
  • Juvelook Volume 200 mg (PLA + HA) – stronger concentration for mid‑face or temple volume loss.
  • Fillunar P200 (200 mg) – PLLA + SCMC – polylactic acid powder with sodium carboxymethylcellulose for soft volumization and collagen building.
  • Fillunar L200 (200 mg) – PLA + HA – hybrid gel combining lactic acid particles and hyaluronic acid.
  • Aesthefill 200 mg – PLLA powder known for full‑face collagen stimulation over 24 months.
  • Belissima 365 mg – high dose PDLLA for substantial collagen induction; often mixed with saline.
  • Ravenna (PDLLA) 200 mg – PDLLA powder for gradual dermal thickening.
  • Exomuhly (3ml × 3) & EXOXE – PDLLA with exosomes for dual collagen and regeneration.
  • Misadi PDLLA 200 mg, Lexyal Plaisir 120/240, Etrebelle 200 mg, Mennus PLA 200 mg, Mennus PLLA 360 mg, Ravello, Ultra PLLA 200 mg, Power COL‑TRA 365 mg, Fillicia 200 mg, Polyboost Vola 600 mg – different PDLLA/PLLA powders with varying densities for tailored collagen stimulation.
  • PCL Power Booster (1 × 2 ml), Touch Up PCL (5 vials) – polylactic‑caprolactone hybrid boosters; they deliver gradual collagen build with added PCL elasticity.
  • Gouri (1 ml × 1) – the first liquid PCL injectable; spreads evenly to trigger natural collagen production across the face.

Pros & Cons

  • Long‑lasting results (18–24 months) once collagen is laid down.
  • Natural look due to your body generating its own collagen.
  • PCL variants (e.g., Gouri) have minimal downtime and smooth distribution.
  • Onset is gradual; results peak after several months.
  • Technique sensitive; requires dilution and correct depth to avoid nodules.
  • Not reversible; not ideal for those seeking immediate plumping or uncertain about volume.

Polynucleotide & PDRN Boosters

Polynucleotides (PN) and polydeoxyribonucleotides (PDRN) are chains of nucleotides derived from salmon DNA. They stimulate the skin’s natural repair processes, boosting fibroblast activity and collagen production, improving elasticity, hydration and texture. Their anti‑inflammatory and antioxidative properties help reduce redness and oxidative stress. Results develop gradually as they support the body’s natural healing pathways.

Notable Products

  • Regenovue PN – pure polynucleotide solution for regenerative mesotherapy.
  • Kiara Reju (2.2 ml × 3) – PN with hyaluronic acid and PDRN for hydration and repair.
  • Rejuner Black Label, Rejuran HB, Rejuran S, Rejuran Healer, Rejuran I, Rejuran Skin Booster, Rejuran Tone Up Booster – a suite of polynucleotide injections targeting fine lines, elasticity, acne scars and overall skin recovery.
  • Rejeunesse Sparkle – combines PN with PLLA micro‑particles for dual repair and collagen stimulation.
  • GemVous PN (2.5 ml × 3) – PN with peptides for revitalization.
  • MisFill+ PDRN (2.2 ml × 3), Syniro (2.2 ml × 2), Hanheal PDRN Booster (5 ml × 5 vials), Recell PDRN Boost (3 ml × 5 vials) – pure salmon‑derived PDRN for anti‑inflammatory repair.
  • HANHEAL HA Ampoule, EVEHILO (1 × 2 ml), Ultrahilo (1 × 2 ml), Hyalace (1 × 2 ml), Revs Pro 32 (1 × 2 ml), AIOR50 (50 mg / 2 ml HA), Ultra Gen (collagen + exosome), HyalMass 50 – hybrid cocktails blending PN/PDRN with hyaluronic acid and peptides for hydration and repair.
  • Youthfill PN (1 × 2.5 ml) – PN with multivitamin complex to stimulate youthful glow.
  • Cindella Healer PN (2 × 2 ml) – PN plus antioxidant cocktail (glutathione & vitamin C) for brightening and repair.
  • Sapphire PDRN (5 ml × 5 vials) – pure PDRN solution for regenerative therapy.

Pros & Cons

  • Supports natural healing and collagen production without adding volume.
  • Ideal for improving texture, hydration and reducing inflammation.
  • Good for acne scars, sun damage, and delicate areas (eyes, neck).
  • Results are subtle and build slowly.
  • Requires a series of sessions for optimal effect.
  • Not a substitute for volume restoration or major lift.

Hyaluronic Acid & Revitalizing Cocktails

Hyaluronic acid (HA) is a hydrophilic molecule that holds 1000 times its weight in water, restoring plumpness and moisture in the dermis. Micro‑injections of deeply hydrating HA improve skin elasticity, firmness and radiance. Many skin boosters combine HA with vitamins, amino acids and coenzymes to revitalize skin by stimulating fibroblasts and restoring density and elasticity.

Notable Products

  • Hyaron (2.5 ml × 10) – low cross‑linked HA solution for hydration and fine line softening.
  • Volassom (0.8 cc × 2) – high‑purity HA gel for micro‑point injections; improves texture and glow.
  • Snow Flower Bloom (2.5 ml × 5 vials) – HA cocktail with antioxidants and peptides for brightening and hydration.
  • NCTF 135 HA (10 × 3 ml) – 60 essential ingredients (vitamins, amino acids, coenzymes) combined with HA that stimulate fibroblasts and restore skin density and elasticity.
  • Revs RMT 140HPn – HA with hyaluronic acid and polynucleotides for hydration and regeneration.
  • Juvederm Skinvive – microdroplet HA filler approved in the US for fine line hydration; provides dewy glow.
  • Revs Pro 32, HyalMass 50, AIOR50, ULTRA Hilo, EveHilo, Hyalace – high‑weight HA fillers/boosters delivered via applicator pens for precision.
  • Regenovue Aquashine Plus Gold & Silver – HA mesotherapy cocktails with peptides and vitamins for glow and firmness.
  • Celosome Aqua (2.5 ml × 5 applicators) – cross‑linked HA for hydration & fine line reduction.
  • Rejuran True Skin Essence (2 ml × 2 applicators) – HA with polynucleotides for improved barrier and repair.
  • GemVous PN & Hyal + peptides (various) – combos of HA, PN and peptides for all‑round revitalization.

Pros & Cons

  • Immediate hydration and plumping effect.
  • Improves elasticity and radiance quickly; minimal downtime.
  • Versatile; can be used alone or combined with other actives.
  • Results may last 4–6 months depending on cross‑linking.
  • Potential for swelling or bruising at injection points.
  • Does not stimulate new collagen unless combined with biostimulators.

Exosome‑Based Boosters

Exosomes are nano‑sized vesicles secreted by stem cells that carry growth factors, proteins and miRNAs. When applied after microneedling, exosomes aid cell‑to‑cell communication and play a crucial role in skin regeneration and repair. They promote collagen production, improve texture, accelerate healing and help even skin tone. Microneedling enhances absorption of the exosome serum into the skin, and noticeable improvements are seen after a series of treatments.

Notable Products

  • EXO 17 V (3 ml vial) & EXO 17 S (2.2 ml) – exosome serums formulated for facial rejuvenation; V stands for volume‑focused version, S for smoothing.
  • EXO 2XSOME (2 vials/1 set) – high‑concentration exosomes for microinfusion treatments.
  • EXOMUHLY (3 ml × 3 vials) & EXOXE – exosomes combined with PDLLA for synergy of regeneration and collagen stimulation.
  • Exosome 17 – general exosome booster for micro‑needling; fosters glow and healing.
  • Exogen for Hair and Skin – exosome solution targeted at scalp and face regeneration.
  • ExoBoom, Botanic EXO, ASCE SRLV – various plant‑ or stem‑cell derived exosome serums for skin repair.
  • GTM Gold Cell Plus (3.3 ml × 10) – exosome and growth factor rich serum for intensive regeneration.
  • Nano exosome combos like ULTRA GEN (Collagen + Exosome) – pairing collagen peptides and exosomes for a one‑two punch of collagen support and regeneration.

Pros & Cons

  • Promotes healthy cell communication and accelerates healing.
  • Improves texture, tone and radiance with minimal downtime.
  • Pairs well with microneedling, RF or lasers to enhance penetration.
  • Requires a series of sessions; effect builds gradually.
  • Quality varies by manufacturer; always ensure source transparency.
  • Cost per vial can be high relative to simpler cocktails.

Brightening & Antioxidant Cocktails

Brightening boosters combine antioxidants (like vitamin C, glutathione and thioctic acid) with hyaluronic acid, peptides or polynucleotides to reduce pigmentation and even skin tone. Vitamin C and glutathione neutralize free radicals and inhibit tyrosinase, decreasing melanin production. Peptides and hyaluronic acid support collagen renewal and hydration.

Notable Products

  • MisAdi White (5 ml × 1) – vitamin C + glutathione + HA + peptides cocktail that brightens, reduces dark spots and supports collagen.
  • Eve White (5 ml × 5) – brightening mesotherapy with glutathione, vitamin C and peptides.
  • Ultra White (3 ml × 5) – potent antioxidant shot for stubborn pigment.
  • Cindella (5 ml × 10A) by DHNP – combination of α‑lipoic acid (thioctic acid) with glutathione and vitamin C; part of the popular “Glutathione + Thioctic Acid + Vitamin C” set for detox and skin whitening.
  • Glutathione + Thioctic Acid + Vitamin C Set (Luthione 1200 mg, Cindella, Vitamin C) – three vials used together for intensive antioxidant therapy.
  • Lemon Skin Booster (3.5 ml × 6) – riboflavin (vitamin B2) with lecithin and bromelain to brighten and improve circulation.
  • Miracle H & L (5 vials each) – hyaluronic acid with glutathione and peptides for hydration and brightening.
  • Sapphire S‑to‑X & Sela‑to X10 – advanced peptide and antioxidant cocktails for pigmentation control.
  • True Healer (3 ml × 1) & Pine Bottle (10 ml × 5) – vitamin‑rich cocktails for overall detox, hydration and glow.
  • AMI Eyes – polynucleotide and antioxidant blend specifically for dark circles.
  • MisAdi White & Ultra White combos – used sequentially for progressive pigment reduction.

Pros & Cons

  • Noticeable brightening and glow when combined with sun protection and good skincare.
  • Anti‑oxidants fight free radical damage and support collagen.
  • Good adjunct for melasma, post‑inflammatory hyperpigmentation and dull skin.
  • Results depend heavily on lifestyle and consistent sun protection.
  • Some formulas may cause temporary flushing or sensitivity.
  • Not a substitute for sunscreen or prescription pigment treatments.

Eye‑Specific Boosters

The delicate under‑eye area requires special formulas that deliver hydration, elasticity, and pigment reduction without causing puffiness. PN, HA and antioxidant blends improve microcirculation, reduce dark circles and fine lines.

Notable Products

  • Clair Eyes (1.1 ml) – polynucleotide solution designed for the under‑eye. Targets dark circles, puffiness and fine lines while improving microcirculation and deep hydration.
  • Ultra Eye (1.1 ml × 1 applicator) – HA and peptides with vitamins for hydration and firming.
  • Spider Aqua Eye Booster (2 ml × 1) – micro‑point injection pen with peptides and HA for tightening.
  • Juve Eye (2 ml × 1) – PN and HA blend for brightening and smoothing.
  • Ami Eyes – PN with antioxidants specifically formulated to reduce dark circles and improve elasticity.
  • EXO 17 S (2.2 ml) – exosome smoothing serum for the eye zone.

Pros & Cons

  • Improves dark circles, fine lines and puffiness without heavy volume.
  • Formulated for delicate tissue; minimal swelling.
  • Great accompaniment to tear‑trough filler or as stand‑alone.
  • Results can be subtle; multiple treatments needed.
  • Careful placement required to avoid lumps or bruising.
  • Not a replacement for volume fillers in hollow tear troughs.

Masks & Peels

Topical boosters in the collection include CO2 masks and chemical peels that enhance treatment results. Carbon dioxide (CO2) masks create a temporary hypoxic environment to increase blood flow, delivering nutrients and oxygen once removed. Exfoliating peels remove dead skin cells, improve tone and boost absorption of injectables.

Notable Products

  • ELAXEN PLLA Mask – sheet mask infused with poly‑l‑lactic acid fragments to support collagen after PLA injections.
  • MisAdi CO2 Mask (5 face + 5 neck) – CO2 mask promoting oxygenation and radiance.
  • Riox CO2 Mask (5 face + 5 neck) – similar carbonic mask for plumping and glow.
  • SoonSu Ultra Reju (3 ml × 5) – vitamin‑rich mask/ampoule hybrid for post‑procedure healing.
  • SoonSu Shining Peel (6 ml × 5) – gentle chemical peel to brighten and remove dead cells.
  • Curenex Snow Peel (4 × 1 g vials) – micro‑dermabrasion powder peel with peptides for smoothing.

Pros & Cons

  • Enhances the effects of injectables by improving circulation and removing dead skin.
  • Non‑invasive; suitable for at‑home use (follow instructions carefully).
  • CO2 masks give immediate glow before events.
  • Results are temporary; used mainly as adjunct care.
  • May cause redness or sensitivity if overused.
  • Not a substitute for in‑clinic treatments.

NAD+ & Cellular Energy Boosters

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme central to cellular energy metabolism and DNA repair. NAD+ boosters and NMN (nicotinamide mononucleotide) cocktails aim to replenish declining NAD+ levels and support healthy cell function. Although research on injectable NAD+ for skin is emergent, many users report improved energy and glow.

Notable Products

  • NMN Bottle NAD+ (5 ml × 10 vials) – combination of NMN and NAD+ precursors for cellular rejuvenation.
  • Hanheal NAD+ – NAD+ booster with additional vitamins for anti‑aging support.
  • Ultra CA Bio Stimulator (2 × 0.8 ml) – calcium hydroxyapatite bio‑stimulator delivering immediate lift and long‑term collagen induction; often paired with NAD+ cocktails.
  • Caratfill Aurora Skin Booster (5.2 ml × 10 vials) – peptides, vitamins and NAD+ precursors for glow and repair.

Pros & Cons

  • Supports cellular energy and DNA repair; may improve overall vitality.
  • Often combined with peptides and vitamins for holistic rejuvenation.
  • Clinical evidence is limited; results vary widely.
  • NAD+ injections can cause flushing or discomfort.

Unique & Miscellaneous Formulations

NutriNation’s catalogue also includes specialty serums and boosters that don't neatly fit into the previous categories. These often combine multiple technologies or target specific concerns.

Notable Products

  • Oasis Repair (2 ml × 2) – vitamin‑rich meso for post‑laser recovery.
  • ExoBoom – blend of exosomes and peptides for rapid post‑procedure healing.
  • High Inj – high‑concentration nutrient injection for deep hydration.
  • Bellacoll (1 × 1 ml) – collagen peptides for subtle smoothing.
  • Ultra Gen (100 mg/3 vials Collagen + Exosome) – mixture of collagen peptides and exosomes for total repair.
  • BVRS PL – peptide and lipid cocktail for skin barrier reinforcement.
  • MeToo Healer PDRN Boost (3 ml × 10 vials) – high‑volume PDRN for professionals treating scars or burns.
  • Recell PDRN Boost (3 ml × 5 vials) – similar to MeToo with regenerative focus.
  • Sapphire S‑to‑X, Sela‑to X10 – multi‑peptide solutions for targeted regeneration.
  • SOSUM Stem Cell Activator (5 vials) – peptides and stem cell factors for intense repair.
  • Hanheal HA Ampoule (5 ml × 5 vials) – high‑concentration HA serum for micro‑needling.
  • Ravenna (PDLLA) & Touch BR – PDLLA powders that can be combined with PN/HA cocktails.

Comparison Table

Category Key Actives Immediate Effect Long‑Term Effect Typical Use Downtime
Collagen Stimulators PLA/PLLA/PDLLA, PCL Minimal (gradual) High (collagen build) Volume loss, laxity Low–moderate (swelling/firmness)
Polynucleotides & PDRN PN, PDRN, PN+HA Subtle hydration Moderate (texture improvement) Scars, fine lines, sensitive areas Low
Hyaluronic Acid Cocktails HA + vitamins + amino acids High (plumping/hydration) Moderate (improved elasticity) Dullness, dryness, fine lines Low
Exosome Boosters Exosomes, growth factors Subtle (glow) Moderate (healing & regeneration) Post‑procedure recovery, rejuvenation Low
Brightening Cocktails Vitamin C, glutathione, peptides Moderate (even tone) Moderate (pigment reduction) Melasma, dullness, uneven tone Low
Eye‑Specific Boosters PN, HA, antioxidants Low–moderate (hydration) Moderate (microcirculation) Dark circles, fine lines Minimal
Masks & Peels CO₂, acids, peptides High (instant glow) Low (temporary) Maintenance, pre‑event Minimal–moderate
NAD⁺ & Misc NAD⁺/NMN, CaHA, peptides Variable Variable Wellness & skin energy Low–moderate

Frequently Asked Questions

How many sessions will I need?

It depends on the product and your goals. Collagen stimulators require 1–3 sessions spaced 4–6 weeks apart. PN and HA cocktails often require 3–4 sessions for optimal results. Exosomes and brightening cocktails are typically done in series of 3–6 sessions. Consult your practitioner for a personalized plan.

Can I mix and match different boosters?

Professionals often layer therapies—for example, start with a collagen stimulator, then use PN boosters and exosomes to refine texture, followed by HA or brightening cocktails. Combining treatments should be done cautiously and spaced appropriately to avoid over‑stimulation. Discuss combination strategies with a trained injector.

How long do results last?

Collagen stimulators last the longest (18–24 months) because they induce your own collagen. HA cocktails last 4–9 months. PN boosters have subtle but cumulative effects over 6–12 months. Brightening cocktails and exosomes may need maintenance every few months.

Is there downtime?

Most boosters have minimal downtime beyond small bumps or redness for 24–72 hours. Collagen stimulators may cause firmness and swelling that lasts a week. Avoid makeup, intense workouts and alcohol for 24 hours after injections, and follow your practitioner’s aftercare.

Disclaimer: This guide provides educational information based on research and publicly available data

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